Research

Academic Research

Dr. Nezhat is devoted to providing the best possible care for his patients. To achieve this, he has focused on perfecting his knowledge and surgical craft throughout his entire career. In conjunction with providing exemplary surgical care, he has contributed prolifically to the medical and scientific literature, widely publishing in both basic and clinical science, as well as in teaching formats such as textbooks and book chapters. He feels the best patient outcomes are derived from evidence-based, reproducible and collaborative initiatives that are subjected to peer review.

A listing of Dr. Nezhat’s research articles can be found at the PubMed search engine, which pulls references and abstracts from the US National Library of Medicine (NLM) database maintained at the National Institutes of Health (NIH).

Over 200 articles are currently attributed to Dr. Nezhat via PubMed and he continues to submit manuscripts for publication.

Selected Articles

Four ovarian cancers diagnosed during laparoscopic management of 1011 women with adnexal masses

Nezhat F, Nezhat C, Welander C, Benigno B. Am J Obstet Gynecol. 1992 Sep;167(3):790-6.

Ovarian cysts are a common indication for hospitalization and surgery, and surgical management had traditionally been performed via midline laparotomy. This publication demonstrates the safety and efficacy of laparoscopy in management of this condition, and that laparotomy may be avoided as long as appropriate protocol is followed.

Comparative immunohistochemical studies of bcl-2 and p53 proteins in benign and malignant ovarian endometriotic cysts

Nezhat F, Cohen C, Rahaman J, Gretz H, Cole P, Kalir T. Cancer. 2002 Jun 1;94(11):2935-40.

The link between endometriosis and ovarian cancer: clinical implications

Nezhat FR, Pejovic T, Reis FM, Guo SW. Int J Gynecol Cancer. 2014 May;24(4):623-8.

Recently, our knowledge of the pathogenesis of ovarian cancer and the role of endometriosis has critically evolved. This manuscript outlines the mechanism for malignant transformation of endometriosis and a rationale for identifying, monitoring, counseling, and treating women with endometriosis who are at highest risk for cancer conversion.

Laparoscopic management of early ovarian and fallopian tube cancers: surgical and survival outcome

Nezhat FR, Ezzati M, Chuang L, et al. Am J Obstet Gynecol. 2009 Jan;200(1):83-85.

This represents one of the largest series and longest follow-ups of laparoscopic staging for early-stage adnexal tumors. Laparoscopic staging of these cancers appears to be feasible and comprehensive without compromising survival when performed by gynecologic oncologists experienced with advanced laparoscopy.

New insights in the pathophysiology of ovarian cancer and implications for screening and prevention

Nezhat FR, Apostol R, Nezhat C, Pejovic T. Am J Obstet Gynecol. 2015 Mar 25. Doi: 10.1016/j.ajog.2015.03.044.

Despite advances in medicine, ovarian cancer remains the deadliest of gynecological malignancies. This manuscript presents the latest information on the pathophysiology of ovarian cancer and its significance for ovarian cancer screening and prevention.

Comparison of perioperative outcomes and complication rates between conventional versus robotic-assisted laparoscopy in the evaluation and management of early, advanced, and recurrent stage ovarian, fallopian tube, and primary peritoneal cancer

Nezhat FR, Finger TN, Vetere P, Radjabi AR, Vega M, Averbuch L, Khalil S, Altinbas SK, Lax D. Int J Gynecol Cancer 2014 Mar;24(3):600-7.

This paper is one of the largest series comparing laparotomy versus conventional laparoscopy versus robotic-assisted laparoscopic management of early, advanced and recurrent stage ovarian, fallopian tube, and primary peritoneal cancer. It shows that perioperative outcomes and complications of robotic and laparoscopy are not worse than laparotomy, while preserving the advantages of minimally invasive surgery over laparotomy.

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